Research Topic · Peer-Reviewed

Vaccine Development

Vaccine development is the multistage scientific and regulatory process by which a biological preparation is designed, tested, and manufactured to elicit protective immunity against a pathogen. It begins with antigen discovery, in which components of the pathogen, such as surface glycoproteins or conserved epitopes,…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 20× across the literature 🔖 ISSN 2692-1537

Overview

Vaccine development is the multistage scientific and regulatory process by which a biological preparation is designed, tested, and manufactured to elicit protective immunity against a pathogen. It begins with antigen discovery, in which components of the pathogen, such as surface glycoproteins or conserved epitopes, are identified as targets capable of inducing neutralizing antibody and cellular responses, and proceeds through platform selection, encompassing inactivated and live-attenuated vaccines, protein-subunit and viral-vector constructs, and nucleic-acid approaches including messenger RNA. Candidates advance through preclinical immunogenicity and safety studies and sequential clinical phases that assess safety, immune response, and efficacy before licensure and post-marketing surveillance. For coronaviruses, the spike glycoprotein has been a principal immunogen, and accelerated development during the COVID-19 pandemic illustrated both the speed achievable with modern platforms and the importance of adjuvants, epitope prediction, and population uptake, including the determinants of vaccine hesitancy and acceptance. The peer-reviewed research grouped under this topic spans COVID-19 vaccine development insights and challenges, predictors of vaccine hesitancy and willingness across populations, computational prediction of B-cell epitopes, nanoadjuvant formulation, and immunological responses relevant to vaccination. Understanding vaccine development is central to virology, immunology, and public health, integrating molecular antigen design, immune mechanism, clinical evaluation, and implementation science to deliver effective and acceptable protection against infectious disease.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 20 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Vaccine Development, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Coronaviruses (ISSN 2692-1537).

Journal editorial board
Dr. Sasho Stoleski · North Macedonia Dr. Omeed Memar · USA Dr. Sudipti Gupta · United States

This page summarises published research for orientation; it is not medical or professional advice.