Editorial Board

Members of the Editorial Board

Select a name or photo to open the editor's profile.

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  Azad Saei

  Editorial Board

  Postdoctoral Research Fellow, Karolinska Institutet, Stockholm, Stockholm County, Sweden

  Research interests: Dendritic cell biology · Immunotherapy · Innate Immunity · Transgenic technology

  ORCID 0000-0002-1000-2953

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  Jean-Pierre Louboutin

  Editorial Board

  University of the West Indies, Mona Campus, Kingston, Jamaica, Gene Therapy Program, University of Pennsylvania., United States

  Research interests: Stem cells · bone marrow · gene therapy · neurology · HIV-1 · HTLV-1 · retroviruses · neurosciences

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  Malgorzata Dobrzyska

  Editorial Board

  National Institute of Public Health, National Institute of Hygiene., Poland

  Research interests: Mutagenesis · micronuclei · comet assay · combined exposure · somatic cells · germ cells · developmental toxicity

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  Sadanand Fulzele

  Editorial Board

  Assistant Professor, Georgia Regents University, Augusta, GA, United States

  Research interests: Bone marrow stromal cells · osteoporosis · bone formation

  ORCID 0000-0002-3510-6759

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  Shanmuganathan Chandrakasan

  Editorial Board

  Emory University, United States

  Research interests: Bone marrow transplant Stem cell stress Novel stem cell conditioning approach Immune deficiency

  ORCID 0000-0001-8007-9932

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  Somanath Padhi

  Editorial Board

  Pondicherry Institute of Medical Sciences, Department of Pathology., India

  Research interests: Hematolymphoid neoplasms · Bone marrow pathology · Cytogenetics · Multiple myeloma · Hemophagocytic lymphohistiocytosis

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  Umberto Galderisi

  Editorial Board

  Second University of Naples, Italy.

  Research interests: Studies on Retinoblastoma gene family He is interested in the studies on genes involved in cell cycle regulation · differentiation · apoptosis and senescence such as the Retinoblastoma (RB) family. He has evaluated the role of Retinoblastoma genes in the regulation of cell proliferation · differentiation and apoptosis in cancer and normal stem cells. In detail · his group has analyzed the biology of neural stem cells and mesenchymal stem cells. These studies prompted the attention also on chromatin remodeling factors that interact with RB family members and play a key role in the life of stem cells. Senescence of stem cells Mesenchymal stem cells (MSCs) are of particular interest because they are being tested in cell and gene therapy for a number of human diseases. MSCs represent a rare population in tissues. Therefore · it is essential to grow MSCs in vitro before putting them to therapeutic use. This is compromised by senescence · limiting the proliferative capacity of MSCs. He is studying the in vitro senescence of rat and human MSCs: In detail · he is interested in analyzing genes involved in DNA repair · whose expression is downregulated with aging. Senescence was accompanied by downregulation of several genes involved in stem cell self-renewal. He studies also the characteristic changes in the expression patters of Retinoblastoma gene family expression that occur during senescence. Epigenetic regulation of stem cell biology Chromatin state is fundamental for gene expression. Self-renewal · proliferation and differentiation properties of stem cells are controlled by key transcription factors. However · their activity is modulated by chromatin remodeling factors that operate at the highest hierarchical level. Studies on these factors can be especially important to dissect molecular pathways governing the biology of stem cells. - SWI/SNF complexes are ATP-dependent chromatin remodeling enzymes that have been shown to be required for cell cycle control · apoptosis and cell differentiation in several biological systems. The aim of our research was to investigate the role of these complexes in the biology of MSCs. - DNA methylation is an epigenetic modification that occurs almost exclusively in the context of CpG dinucleotides. MECP2 is a member of a family of proteins that preferentially bind to methylated CpGs. We are analyzing the specific contribution of MECP2 in physiology of mesenchymal stem cells (MSCs). - Histone deacetylase inhibitors (HDACi) have received great attention for their anti-tumoral properties. This anti-cancer action can be obtained by reversion of silenced genes · induction of cell cycle arrest · differentiation and/or apoptosis. HDACi-based therapy can have side effects that impair functions of bone marrow microenvironment · including MSCs. We are studying the biological effects of HDACi on MSCs. Mesenchymal stem cells from basic to applied sciences Restenosis following vascular injury remains a pressing clinical problem · despite continuous improvements of medical strategies. The possible therapeutic role of MSCs in a model of vascular injury in vivo has not been determined so far. His group is testing the homing and the effectiveness of MSCs in reduction of (re)stenosis in a model of arteriotomy of rat common carotid

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  Ying Li

  Editorial Board

  Associate professor and Director of Hematopathology, Dept. of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine., United States

  Research interests: Medicine