Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing
articles matching Phenotype — open any to read the full text,
or download the PDF or XML.
Jan 2019 DOI 10.14302/issn.2641-5526.jmid-18-2529
Juan Luis Fernández-MartínezCorresponding author
Discrimination of case-control status based on gene expression differences has potential to identify novel pathways relevant to neurodegenerative diseases including Parkinson’s disease (PD). In this paper we applied two different novel algorithms to predict dysregulated pathways of gene expression a…
Aug 2018 DOI 10.14302/issn.2639-3166.jar-18-2264
Giorgio MasoeroCorresponding author
The management of symbiotic Microbial Biota (MB) in the soil as agents that promote the yield and health of crops, is aimed at inducing modifications of the phenotype of plants, both over and under the ground. It is here shown, in Sorghumsudanensis plants, that: i) a simple response to MB inoculatio…
May 2018
Ioannis AlatsathianosCorresponding author
Genetics alone cannot thoroughly expound the environmental impact on the molecular complexity of the endocrine system. Epigenetic-induced alteration in gene expression has emerged as a way in which environmental compounds may exert endocrine effects. The environmental compounds that interfere with n…
Nov 2017 DOI 10.14302/issn.2576-6694.jbbs-17-1748
Ajay NairCorresponding author
Neo-Darwinian natural selection theory indicates that sudden, drastic changes in the environment place selective pressure on genetic variants in a population. As time progresses, this pressure sculpts individuals to better fit this new environment. Waddington’s classic experiment was repeated using…
Jun 2017 DOI 10.14302/issn.2474-7785.jarh-17-1578
Daisy WilsonCorresponding author
Frailty describes a medical syndrome that confers increased vulnerability to disproportionate changes in health status following minor stressors. With loss of homeostatic reserve in multiple physiological systems, frailty conveys an increased risk of adverse health outcomes. Despite the lack of a cl…
Jun 2016 DOI 10.14302/issn.2470-5020.jnrt-16-993
Karin Jurkat-RottCorresponding author
Autosomal dominant inherited hypokalemic periodic paralysis (HypoPP) is caused by S4 voltage sensor mutations in skeletal muscle CaV1.1 calcium or NaV1.4 sodium channels. In the present study, a small German family with the known CaV1.1-R528G is described. The phenotype consists of short and infrequ…
Jul 2013 DOI 10.14302/issn.2326-0793.jpgr-13-207
Joanna FlorosCorresponding author
Surfactant protein A (SP-A) plays a number of roles in lung host defense and innate immunity. There are two human genes, SFTPA1 and SFTPA2, and evidence indicates that the function of SP-A1 and SP-A2 proteins differ in several respects. To investigate the impact of SP-A1 and SP-A2 on the alveolar ma…