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Jan 2018 DOI 10.14302/issn.2471-2140.jaa-17-1927
V.I. PetukhovCorresponding author
The work is dedicated to the problem of the norm in the quantitative evaluation of metal content in the epidermal cells (hair) obtained by the method of spectrometry. Authors have analyzed the hair samples for Zn, Cu, and Fe content, which were obtained from 10000 healthy subjects (5000 males and 50…
Jan 2018 DOI 10.14302/issn.2578-8590.ipj-17-1910
William J FosterCorresponding author
Following ocular trauma and retinal detachment, gliotic changes in the retina may develop over the subsequent month, a process known as PVR (proliferative vitreoretinopathy). There have been no successful therapeutic interventions to inhibit PVR. The protein CTGF (Connective Tissue Growth Factor) ha…
Jul 2017 DOI 10.14302/issn.2574-4372.jesr-17-1611
Zhen HeCorresponding author
Neural stem cell activity at least partially accounts for the postweaning development of the sexually dimorphic nucleus of the preoptic area (SDN-POA) and estrogen selectively mobilizes neural stem cells in the 3rd ventricle stem cell niche (3VSCN). Here, we examined the expression of estrogen recep…
Feb 2017 DOI 10.14302/issn.2574-4372.jesr-16-1380
Huafeng WeiCorresponding author
General anesthetics (GAs) are widely used for various essential surgical or medical procedures. Recent studies implicate the GAs has dual effects of neuroprotection and neurotoxicity on neurogenesis with unclear mechanisms. This minireview summarizes recent studies on GAs mediated effects on neuroge…
Jan 2017 DOI 10.14302/issn.2574-4372.jesr-16-1327
Cristina ZaniniCorresponding author
Stem cell-based regenerative therapy can be considered an innovative approach for curing dental caries. Pulp stem cells from human exfoliated deciduous teeth (SHEDs) represent a source of committed cells for generating odontoblasts in vitro; however, SHEDs are not easy to obtain and are limited in q…
Jun 2016 DOI 10.14302/issn.2372-6601.jhor-16-1125
Jun-ya KatoCorresponding author
Senescence is a powerful mechanism that prevents the development of tumors in vivo; however, once tumors are formed, most are refractory to senescence in response to oncogenic stress. Therefore, a novel pathway leading to senescence is required. We herein demonstrated that the cell cycle regulator C…
Mar 2016 DOI 10.14302/issn.2470-0436.jos-15-739
Vijay P. SarthyCorresponding author
Ciliary neurotrophic factor (CNTF) is a well-tested, neuroprotective agent that has been shown to retard photoreceptor degeneration in several animal models of retinitis pigmentosa. The molecular mechanisms underlying CNTF-mediated neuroprotection are currently not understood. CNTF could act directl…
Feb 2016 DOI 10.14302/issn.2372-6601.jhor-15-822
I.V. ChernikovCorresponding author
Institute of Chemical Biology and Fundamental Medicine SB RAS.
Small interfering RNA (siRNA) based drugs for overcoming multiple drug resistance of hematological malignancies could solve the problem of poor response to the chemotherapy and hight relapse rate. The main factor that significantly limits biomedical application of siRNA is inefficient delivery to ta…
Feb 2016 DOI 10.14302/issn.2574-4496.jtc-15-838
Daniel ChristopheCorresponding author
Thyroid transcription factor-1 (TTF-1) is known to play key roles in thyroid organogenesis, in thyroid cell proliferation and in the expression of genes involved in thyroid differentiated function. Many human thyroid cancer cell lines keep producing TTF-1 despite the loss of differentiated gene expr…
Dec 2015 DOI 10.14302/issn.2471-2140.jaa-15-765
Zaijun ZhangCorresponding author
Reactive oxygen species (ROS) and reactive nitrogen species are believed to be one of the most important culprits in the pathogenesis of cardio/cerebrovascular diseases. Intensive researches have been conducted to target free radicals as potential treatment for cardio/cerebrovascular diseases. The 2…
Jun 2015 DOI 10.14302/issn.2574-4372.jesr-14-607
Michael E. GeuszCorresponding author
Cancer is influenced by the ability of cells to maintain circadian rhythms in molecular and metabolic processes. Disturbance of the underlying circadian timing mechanism in circadian clock cells leads to a higher frequency and more rapid progression of cancer. Cancer stem cells with properties of em…
May 2015 DOI 10.14302/issn.2471-7061.jcrc-14-574
Rosalyn B. IrbyCorresponding author
Colon cancer has a five-year survival of 64.7%, and about 50,000 people are expected to die from colon cancer this year. Patients with metastatic colorectal cancer have a significantly worse prognosis, a 12.9% five-year survival. This emphasizes the need for strategies to inhibit the growth and meta…
May 2015 DOI 10.14302/issn.2372-6601.jhor-14-493
E PrunierCorresponding author
In autologous hematopoietic stem cell transplantation patients for whom granulocyte-colony stimulating factor fails to mobilize a sufficient number of peripheral blood stem cells, plerixafor proposes an option for successful rescue mobilization. This paper evaluates the efficacy of plerixafor to mob…
Mar 2015 DOI 10.14302/issn.2379-8572.joa-14-611
Travis ShibaCorresponding author
Vocal fold scarring is a clinical problem without reliable treatment. Tissue engineering of a vocal fold replacement is an exciting potential treatment for vocal fold scars that involve multiple layers of the vocal fold. Human adipose-derived stem cells (ASC) were previously used to produce a promis…
Dec 2014 DOI 10.14302/issn.2326-0793.jpgr-14-598
Kim YC FungCorresponding author
Colorectal cancer is one of the most commonly diagnosed cancers worldwide and its prevalence can be reduced by changes to lifestyle and diet. Fermentation of dietary fibre by the gut microbiota and formation of short chain fatty acids, in particular butyrate, is widely thought to play a role in prev…
Mar 2014 DOI 10.14302/issn.2372-6601.jhor-13-362
Spiros A. VlahopoulosCorresponding author
A narrative review summarizes how fenofibrate influences cancer cell metabolism and proliferation. It reviews PPAR‑α–dependent and independent mechanisms, context‑specific effects, and implications for repurposing studies.
Jan 2014 DOI 10.14302/issn.2328-0182.japst-12-183
Supriya D. MahajanCorresponding author
Gold nanorods (GNRs) are plasmonic nanostructures by virtue of their size-dependent optical properties, offer a bionanotechnology platform in areas of bioimaging, drug delivery etc for disease diagnosis, prognosis, and therapy. GNRs are more sensitive to changes in local environments, and offer stro…
Dec 2012 DOI 10.14302/issn.2326-0793.jpgr-12-100
Shitao LiCorresponding author
Defining protein-protein interactions is essential for understanding the mechanisms by which cells regulate basic functions, such as metabolism, transcription, and signal transduction. Affinity purification followed by tandem mass spectrometry (AP-MS) has application for discovery of new interactors…
Sep 2026
Yilkal Tariku BelayCorresponding author
Immunoglobulins, commonly known as antibodies, are glycoprotein molecules present on B lymphocytes and within the bloodstream. They are essential components of the immune response, as they detect the harmful molecules of test compounds and stimulate the immune system to manifest proportional counter…
Aug 2026 DOI 10.14302/issn.2473-1005.jdoi-26-6193
Cameron Y. S. LeeCorresponding author
Regeneration of new bone continues to be one of the most significant challenges in implant dentistry to correct osseous deficiencies in preparation for dental implant surgery. The need for effective bone regenerative strategies has fueled the development of many therapeutic methods, including the us…