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Aug 2017 DOI 10.14302/issn.2575-7881.jdrr-17-1701
Wentao XuCorresponding author
Functional nucleic acids are a kind of nucleic acid sequences with special functions, which can specifically bind with the target substances or catalyze the reactions. Many target, including mycotoxins, small RNA, heavy metal ions and DNA segment, can bind to particular selected oligonucleotides, an…
Jun 2017 DOI 10.14302/issn.2576-9359.jot-17-1603
Carlotta CapraraCorresponding author
Single-nucleotide polymorphisms (SNPs) in genes involved in immune responses and in the pharmacokinetics/pharmacodynamics of immunosuppressive drugs influence transplant outcomes of patients receiving the same immunosuppressive therapy. The aim of our preliminary study was to determine the SNPs prof…
Apr 2017 DOI 10.14302/issn.2372-6601.jhor-17-1463
Sylwia SzablewskaCorresponding author
Melanoma is considered to be a very aggressive cancer due to its rapid growth, early and multiple metastases and limited response to standard treatment. Many researchers have hypothesized that the combination of radiation therapy and immunotherapy in the treatment of melanoma primary tumors and meta…
Jan 2017 DOI 10.14302/issn.2572-3030.jcgb-16-1307
Rafael MoralesCorresponding author
Interpreting variants of uncertain significance (VUS) for their effect on protein function, and therefore for the risk of developing cancer, has become a challenge in clinical practice for genetic counselling services. The present work combines structural bioinformatics and systems biology based mat…
Jan 2017 DOI 10.14302/issn.2575-7881.jdrr-16-1375
László GóthCorresponding author
We checked our simple screening technique for detection of the known polymorphism of rs769217, and the two acatalasemic mutations in exon 9 of the catalase gene. This fast and inexpensive method yielded better resolution than those of the standard SSCP. We suppose that the method detects the spontan…
Oct 2016 DOI 10.14302/issn.2572-3030.jcgb-16-1190
Ibtihal omerCorresponding author
Background: Gastric cancer (GC) ranks as the fourth most common cancer and the second leading cause of cancer deaths worldwide. Epstein-Barr virus is a well-known oncogenic virus, it is responsible for 10% of gastric carcinomas across the world. The aim of study was to determine the prevalence of EB…
Jul 2016 DOI 10.14302/issn.2381-862X.jwrh-15-806
Badr AbdullGaffarCorresponding author
Background and Objectives: The prevalence of abnormal cervical cytology in morbidly obese women using ThinPrep® liquid-based Pap Test™ and HPV DNA Test™ is unknown. We aimed to investigate whether women with morbid obesity have a higher frequency of abnormal Pap smears compared with nonobese women,…
Jun 2016
Arup Ratan BandyopadhyayCorresponding author
Earlier studies reported significant association of obesity, hypertension and Type2 Diabetes Mellitus (T2DM). Genetic and many disease-associated alleles have been identified through GWAS and applied to T2DM and indicated roles of renin-angiotensin system (RAS) in insulin signaling pathway and insul…
Apr 2016 DOI 10.14302/issn.2575-7881.jdrr-15-863
Miguel A. FuertesCorresponding author
It was, previously, reported that the specific pattern of the compositional features of particular human-mouse orthologs defining in human two clusters, named C2 and C5, are present in different clusters in mouse. Since, thus, these orthologs can harbor a significant number of nucleotide differences…
Feb 2016 DOI 10.14302/issn.2374-9431.jbd-15-890
Norman E. BurokerCorresponding author
Purpose Signal Transducer and Activator of Transcription 4 (STAT4) is important for signaling by interleukins (IL-12 and IL-23) and type 1 interferons and has been found to have several simple nucleotide polymorphisms (SNPs) associated with human disease. STAT4 SNPs were computationally examined wit…
Feb 2016 DOI 10.14302/issn.2326-0793.jpgr-15-889
Norman E. BurokerCorresponding author
Purpose The endothetal Per-Arnt-Sim (PAS) domain protein 1 (EPAS1) gene which encodes hypoxia-inducible-factor-2 alpha (HIF2a) is a transcription factor that is involved in the response to hypoxia. EPAS1 has been found to have four (rs56721780, rs6756667, rs7589621, rs1868092) simple nucleotide poly…
Jan 2016 DOI 10.14302/issn.2379-8572.joa-15-814
Mohammad FarhadiCorresponding author
Background and Objective: The etiological factors for nasal polyps include infection, inflammation or an imbalance of a metabolic pathway. This study was designed to compare serum Helicobacter pyloriantibodies and H. pylori–DNAs between cases of nasal polyp and controls (nasal fracture). Patients an…
May 2015 DOI 10.14302/issn.2379-7835.ijn-14-603
Kenneth LundstromCorresponding author
Epigenetic mechanisms based on DNA methylation, histone modifications and RNA interference have recently showed important association to the development of a wide variety of diseases such as cancer, cardiovascular, metabolic, skin, autoimmune diseases and neurologic disorders. In the context of prev…
Jan 2015 DOI 10.14302/issn.2379-7835.ijn-14-606
Michael J. GladeCorresponding author
Telomeres are strings of DNA that are not themselves genes but that extend every chromosome beyond its last gene. Terminal telomeres are sacrificed during every mitotic event in human cells (“telomere attrition”), preserving the functional genome despite the “end replication problem.” However, the “…
Dec 2014 DOI 10.14302/issn.2326-0793.jpgr-14-598
Kim YC FungCorresponding author
Colorectal cancer is one of the most commonly diagnosed cancers worldwide and its prevalence can be reduced by changes to lifestyle and diet. Fermentation of dietary fibre by the gut microbiota and formation of short chain fatty acids, in particular butyrate, is widely thought to play a role in prev…