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Mar 2016 DOI 10.14302/issn.2326-0793.jpgr-16-941
Christina ChanCorresponding author
In contrast to approaches that compare pair-wise control (i.e. normal) to treated (i.e. disease) samples, we compared colorectal cancer samples not only to a set of control samples but also against a wide range of samples and conditions to collect the differentially expressed genes and identify targ…
Mar 2016 DOI 10.14302/issn.2997-2108.jcc-15-856
Hanan PolanskyCorresponding author
This paper explores the potential of Gene‑Eden‑VIR as an adjunctive approach for cervical cancer prevention or management. The discussion reviews proposed antiviral and immunomodulatory mechanisms, existing evidence, and safety considerations. The authors call for controlled trials to clarify effica…
Mar 2016 DOI 10.14302/issn.2474-3585.jpmc-15-757
Hong LiuCorresponding author
Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032,Shaanxi Province, China
Objective: MicroRNAs are involved in the onset, progression and dissemination of esophageal cancer, and they may be useful as prognostic biomarkers. This study aims to evaluate the relation of miR-21 expression and the prognosis of esophageal cancer patients. Methods: In this study, a meta-analysis…
Mar 2016 DOI 10.14302/issn.2471-7061.jcrc-15-899
Lewis K. ShinCorresponding author
Missed cancers have been reported at higher frequencies in the right colon despite optical colonoscopy screening. The purpose of this study was to determine if there are regional differences in haustral fold height between the ascending, transverse, and descending colon using CT colonography (CTC).…
Feb 2016 DOI 10.14302/issn.2574-4496.jtc-15-838
Daniel ChristopheCorresponding author
Thyroid transcription factor-1 (TTF-1) is known to play key roles in thyroid organogenesis, in thyroid cell proliferation and in the expression of genes involved in thyroid differentiated function. Many human thyroid cancer cell lines keep producing TTF-1 despite the loss of differentiated gene expr…
Oct 2015 DOI 10.14302/issn.2379-8572.joa-15-691
Hany Abdel RahmanCorresponding author
Background. Nasopharyngeal carcinoma (NPC) is a rare disease in the pediatric age group; it represents 1% of all pediatrics malignancies, however, it is the predominant malignancy arising in the nasopharynx in this age group. Although NPC is a chemo-radiosensitive disease yet, the optimal dose of ra…
Jun 2015 DOI 10.14302/issn.2574-4372.jesr-14-607
Michael E. GeuszCorresponding author
Cancer is influenced by the ability of cells to maintain circadian rhythms in molecular and metabolic processes. Disturbance of the underlying circadian timing mechanism in circadian clock cells leads to a higher frequency and more rapid progression of cancer. Cancer stem cells with properties of em…
May 2015 DOI 10.14302/issn.2471-7061.jcrc-14-574
Rosalyn B. IrbyCorresponding author
Colon cancer has a five-year survival of 64.7%, and about 50,000 people are expected to die from colon cancer this year. Patients with metastatic colorectal cancer have a significantly worse prognosis, a 12.9% five-year survival. This emphasizes the need for strategies to inhibit the growth and meta…
May 2015 DOI 10.14302/issn.2574-4496.jtc-14-395
Amal AlhefdhiCorresponding author
Background: Medullary Thyroid Cancer (MTC) is a rare malignancy, accounting for less than 3% of all thyroid cancers and causes significant morbidity and mortality. MTC is often due to an underlying mutation of the RET proto-oncogene, which can result in additional endocrinopathies that must be scree…
Jan 2015 DOI 10.14302/issn.2471-7061.jcrc-14-394
Petros C. PapagiorgisCorresponding author
This review synthesizes evidence on NSAIDs and colorectal cancer prevention. It balances chemopreventive efficacy against gastrointestinal and cardiovascular risks, and considers selective COX‑2 inhibitors, dosing, and candidate populations for risk‑benefit.
Dec 2014 DOI 10.14302/issn.2326-0793.jpgr-14-598
Kim YC FungCorresponding author
Colorectal cancer is one of the most commonly diagnosed cancers worldwide and its prevalence can be reduced by changes to lifestyle and diet. Fermentation of dietary fibre by the gut microbiota and formation of short chain fatty acids, in particular butyrate, is widely thought to play a role in prev…
May 2014 DOI 10.14302/issn.2572-3030.jcgb-13-369
Ashraf KhanCorresponding author
Insulin receptor substrate (IRS) 1 and 2 are downstream signaling proteins that influence breast pathophysiology. IRS-1 promotes carcinoma cell proliferation; whereas IRS-2 regulates cell motility, invasion, and glycolysis. Our lab has shown that distinct cellular localization of IRS-2 also plays a…
Mar 2014 DOI 10.14302/issn.2372-6601.jhor-13-362
Spiros A. VlahopoulosCorresponding author
A narrative review summarizes how fenofibrate influences cancer cell metabolism and proliferation. It reviews PPAR‑α–dependent and independent mechanisms, context‑specific effects, and implications for repurposing studies.
A. S. Sardenberg RodrigoCorresponding author
Chief of Thoracic Surgery, Hospital Paulistano, Americas Serviços Médicos São Paulo, Brazil
Distant metastases generally indicate disseminated disease and the standard treatment for these patients is palliative chemotherapy. Retrospective series showed that selected patients with metastatic lung cancer and a solitary extrathoracic disease could be effectively treated with curative intentio…
Aug 2026
Manjula Reddy PallerlaCorresponding author
Cyclic peptides are expected to play a significant role in the future of drug discovery and development. Their unique properties, such as enhanced target affinity, metabolic stability, and favorable pharmokinetic profiles, make them promising candidates for addressing complex therapeutic targets. In…
Aug 2026 DOI 10.14302/issn.2377-2549.jndc-26-6392
Grigorii G. SivetsCorresponding author
Chemoenzymatic synthesis of a series of purine modified 3′ deoxyribonucleosides was studied from purine derivatives as acceptors and an excess of 3′-deoxyuridine as the donor, prepared by the chemical deamination of 3′-deoxycytidine, using recombinant uridine and purine nucleoside phosphorylases as…
May 2026 DOI 10.14302/issn.2642-3146.jec-26-6199
Kung-Ming ChungCorresponding author
Solar thermal heating is a mature technology for producing hot water in the domestic sector. Industrial processes require significant heat, so solar water heaters can be used for pre-heating. A forced- circulation solar water heater is installed in a feed plant that is located south of the Tropic of…
Mar 2026 DOI 10.14302/issn.2641-9181.ijnr-25-5844
Michael TraunerCorresponding author
A sequence variation (I148M) in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene has been linked to metabolic dysfunction-associated steatotic liver disease (MASLD) and the progression of MASLD and other chronic liver diseases towards fibrosis and cancer. To elucidate the rol…
Feb 2026 DOI 10.14302/issn.2372-6601.jhor-25-5944
Mikhail Y. BerezinCorresponding author
Background Oxaliplatin, a widely used chemotherapeutic agent, is associated with hematologic toxicities such as anemia, leukopenia, and thrombocytopenia. Despite their clinical relevance, the molecular mechanisms underlying lineage-specific bone marrow suppression remain poorly understood. Methods W…
Feb 2026
Sunil SinghalCorresponding author
Objective The landscape of non-small cell lung cancer (NSCLC) has changed due to liberalized utilization of computed tomography, developments in immunotherapy and targeted treatments, and guidelines encouraging sublobar resections. We analyzed the implications of these advances for surgical procedur…