Search results for “disease”

About 100 results in articles

Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing articles matching disease — open any to read the full text, or download the PDF or XML.

Anti-DPPX-Encephalitis in A Patient with Cerebral Vasculitis and Connective Tissue Disease

Jan 2018 DOI 10.14302/issn.2470-5020.jnrt-17-1926
Simon NagelCorresponding author

Since the first description in 2013, 39 cases of anti-DPPX-encephalitis have been described. Main features of this autoimmune encephalitis characterized by antibodies against the potassium-channel-associated regulatory protein DPPX are gastrointestinal symptoms, cognitive dysfunction and signs of CN…

Advanced Virological And Clinicopathological Studies On Cattle Suffering From Foot And Mouth Disease Virus

Sep 2017 DOI 10.14302/issn.2577-137X.ji-17-1736
Samia Ahmed KamalCorresponding author

Some strains of Foot and mouth disease virus (FMDV) are endemic in Egypt. The present study was performed on cattle and buffaloes (ages: 3 months up to 1.5 years old, of years 2015 and 2016), which were suffering foot and mouth disease (FMD). Sera and tissues samples were tested by different techniq…

Development of a Chronic Obstructive Pulmonary Disease Severity Classification System Using A Japanese Health Insurance Claims Database

Sep 2017 DOI 10.14302/issn.2474-7785.jarh-17-1727
Manabu AkazawaCorresponding author

Background: Healthcare services provided to patients should vary depending on disease severity. However, disease severity bias, a type of selection bias, is a commonly encountered problem in administrative database studies. Herein, we selected chronic obstructive pulmonary disease (COPD), which comm…

A Model for Identifying Actionable Findings on Computed Tomography in Crohn’s Disease Patients in the Emergency Department

Aug 2017 DOI 10.14302/issn.2574-4526.jddd-17-1688
Kian KeyashianCorresponding author

Patients with inflammatory bowel disease (IBD) frequently visit the emergency department (ED). The use of cputed tomography (CT) scans in this population has drastically increased in recent years and may confer an increased risk of malignancy. Records were obtained for IBD patients aged 18 or older…

Early Versus Late Immunomodulatory Therapy in Vogt-Koyanagi-Harada disease

Aug 2017 DOI 10.14302/issn.2470-0436.jos-17-1666
Philip P. StoreyCorresponding author

Purpose: To evaluate early versus late immunomodulatory therapy (IMT) for patients following initial diagnosis of Vogt-Koyanagi-Harada (VKH) disease. Methods: Retrospective review including all VKH patients seen 5/1/2014 to 4/1/2016 at LAC+USC. Early IMT was defined as starting an immunomodulatory a…

Morphological and Functional Abnormalities of the Thyroid Gland among End Stage Kidney Disease Patients

Aug 2017 DOI 10.14302/issn.2372-6601.jhor-17-1606
O OsmanCorresponding author Consultant nephrologist, Alqunfudah Hospital, KSA.

Several interactions exist between thyroid and kidney function in many disorders. Many publications explored the relationship between thyroid diseases (TD) and chronic kidney diseases (CKD). However, the morphological thyroid changes in patients with CKD or End Stage Kidney disease (ESKD) were not f…

A Role for in Vitro Disease Models in the Landscape of Preclinical Cardiotoxicity and Safety Testing

Jul 2017 DOI 10.14302/issn.2574-4372.jesr-17-1705
Vijayalakshmi VarmaCorresponding author

Drug-induced cardiotoxicity is one of the predominant reasons for drug attrition and withdrawals. This is of critical concern when potentially cardiotoxic drugs are administered to individuals with inherited arrhythmogenic cardiac diseases or with metabolic diseases such as obesity and diabetes, whi…

Increased Level of Lactate Dehydrogenase Correlates with Disease Growth in Algerian Children with Lymphoma

Jul 2017 DOI 10.14302/issn.2372-6601.jhor-17-1473
R RaacheCorresponding author Laboratoire des cytokines et NO Synthases (FSB-USTHB), Université des Sciences et de la Technologie Houari Boumediene (USTHB), Alger, Algérie

Objective: This study aimed to evaluate the relation of Lactate dehydrogenase (LDH) levels with stage of the disease and it role in monitoring tumor response to therapy in lymphoma patients. Methods. LDH levels were evaluated on 65 diagnosed Algerian children and compared to healthy control. Results…

Pharmaceutical intervention on Ca2+/cAMP signaling interaction: benefits for combating neurodegeneration and diseases related to aging

Jul 2017 DOI 10.14302/issn.2577-2279.ijha-17-1587
Leandro Bueno BergantinCorresponding author

This review explores crosstalk between Ca2+ and cAMP signaling and its therapeutic implications for neurodegeneration and aging. It summarizes candidate interventions and translational challenges.

MicroRNA: New Era for Therapeutic Strategy in Ischaemic Heart Disease

Jun 2017 DOI 10.14302/issn.2329-9487.jhc-17-1536
Md. Kamrul HossainCorresponding author

Over the last few decades, many research works highlighted the role of miRNAs on cardiac diseases. Ischaemic heart disease (IHD) or coronary heart disease is a condition that is mainly caused by atherosclerosis. It has been established that microribonucleic acids regulate many factors that are invol…

Single Daily Activity or Exercise Capacity Measurements Did not Predict Future Changes in Cardiovascular Risk Factors in Congenital Heart Disease

Jun 2017 DOI 10.14302/issn.2329-9487.jhc-17-1493
Jan MüllerCorresponding author

Objective: Studies suggest that cardiovascular risk of patients with congenital heart disease (CHD) is increased. This study aims on the predictive value of a single daily activity and exercise capacity assessments on the change of body-mass-index (BMI) and blood pressure in the future. Patients and…

Rescuing Canavan Disease by Redirecting Metabolic Processing: Support for the Astrocyte Hypothesis of Canavan Disease Generation and A Possible Human Cure

Apr 2017 DOI 10.14302/issn.2572-5424.jgm-17-1482
Morris H BaslowCorresponding author

Canavan disease (CD) is a globally occurring but rare human spongiform leukodystrophy that is associated with inborn errors affecting the activity of aspartoacylase (ASPA), an enzyme highly expressed in oligodendrocytes that hydrolyzes N-acetylaspartate (NAA). Lack of ASPA activity is associated wit…

Differentiating Depression from Apathy in Chronic Kidney Disease: A Prospective Study

Mar 2017 DOI 10.14302/issn.2476-1710.jdt-16-1262
R. SchoenfeldCorresponding author

Background. Emotional deterioration is frequently found in patients with chronic kidney disease, but some patients are affected by depressed mood without fulfilling the criteria of a depressive disorder. Those patients might rather suffer from an apathy symptom. Apathy as a symptom of a medical dise…

Bioinformatic Analysis of Coronary Disease Associated SNPs and Genes to Identify Proteins Potentially Involved in the Pathogenesis of Atherosclerosis

Mar 2017 DOI 10.14302/issn.2326-0793.jpgr-17-1447
Timothy D. HowardCorresponding author

Factors that contribute to the onset of atherosclerosis may be elucidated by bioinformatic techniques applied to multiple sources of genomic and proteomic data. The results of genome wide association studies, such as the CardioGramPlusC4D study, expression data, such as that available from expressio…

Evaluation of Vitamin D Deficiency in Patients with Chronic Liver Disease and Its Clinical Significance

Dec 2016 DOI 10.14302/issn.2379-7835.ijn-16-1381
Bal Kishan GuptaCorresponding author

Introduction: Vitamin D deficiency has been reported highly prevalent in Chronic liver disease (CLD) and there is an emerging interest to explore the relationship of vitamin D deficiency and severity of various types of CLD. Aim: To evaluate vitamin D level in patients with various type of CLD and c…

Prevalence of Impulse Control Disorders among Adult Filipino Patients with Idiopathic Parkinson’s Disease seen at Jose R. Reyes Memorial Medical Center

Oct 2016 DOI 10.14302/issn.2470-5020.jnrt-16-1240
Jan Kristoper P. de GuzmanCorresponding author

Background: Impulse Control Disorders (ICDs) are characterized as pathologicalbehavioral patterns of excess impulsivity which may result as part of the non-motor complications of Parkinson’s disease (PD). These significantly affect the patient’s overall quality of life and have impact on their care…

Distinguishing between Knowledge Gaps and Misconceptions of Alzheimer’s Disease among Caregivers in the UK

Oct 2016 DOI 10.14302/issn.2474-7785.jarh-16-1128
Petra M. J. PolluxCorresponding author

A popular scale for assessing knowledge about Alzheimer’s disease is the Alzheimer’s Disease Knowledge Scale (ADKS). The aim of the study was to investigate the effect of adding ‘don’t know’ to the original ‘true’ or ‘false’ response option. It was assumed that this modification would provide insigh…

Psychological “Risks” of Colonoscopy are Greater Amongst Fecal Immunohistochemical Test Positive Individuals than those with Inflammatory Bowel Disease

Aug 2016 DOI 10.14302/issn.2471-7061.jcrc-14-426
Réme MountifieldCorresponding author

Background: Colorectal cancer (CRC) screening by Fecal Immunohistochemical Testing (FIT) followed by colonoscopy reduces colorectal cancer mortality. Barriers to colonoscopy should be minimised. Objective: To compare psychological “risks” of colonoscopy in FIT positive (FIT+) subjects and those with…

Muscle Activation Signals During Gait Parkinson’s Disease are More Rhythmic than in Healthy Controls

Aug 2016 DOI 10.14302/issn.2470-5020.jnrt-15-750
Timothy Adam ThrasherCorresponding author

Background To quantify the underlying rhythmic patterns observed in surface electromyography (SEMG) in patients with Parkinson’s Disease (PD), to compare rhythmicity of PD gait with normal gait, and to compare overground walking to treadmill gait. Methods Eight individuals with idiopathic PD, and te…

Organic or Psychiatric Disease? A Misdiagnosed Superior Mesenteric Artery Syndrome

Aug 2016 DOI 10.14302/issn.2379-7835.ijn-16-1154
Giardino S. Neri F.Corresponding author Centre of Rare Diseases of the Sicilian Region, University of Catania, Italy

Superior mesenteric artery syndrome 1234 is a rare disorder characterised by a compression of the duodenum because of the reduced angle between the aorta and superior mesenteric artery. The disease is clinically characterised by abdominal pain, lack of appetite, vomiting and anorexia; some of these…

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