Search results for “glycosyl chloride”

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Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing articles matching glycosyl chloride — open any to read the full text, or download the PDF or XML.

1 article
Journal of New Developments in Chemistry Open Access

Synthesis of 2-Chloro-2′-Deoxyadenosine (Cladribine) and New Purine Modified Analogues

Nov 2021 DOI 10.14302/issn.2377-2549.jndc-21-4017
Grigorii SivetsCorresponding author

Theefficient two-step synthesis of 2-chloro-2′-deoxyadenosine (cladribine) via the anion glycosylation of purine potassium salt with the glycosyl chloride in binary solvent mixtures is described. A new method for preparation of diprotected 2-chloro-6-fluoropurine 2′-deoxy-β- D-riboside was developed…

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