Search results for “mechanism”

About 100 results in articles

Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing articles matching mechanism — open any to read the full text, or download the PDF or XML.

Health System Support Mechanisms for HIV Status Disclosure Among People Living with HIV/AIDS in Mukono District, Uganda

Mar 2026
Perry GambaCorresponding author

Background Health systems play a crucial role in supporting HIV status disclosure, which is essential for HIV prevention, treatment adherence, and psychosocial support. Understanding how health systems support disclosure is vital for improving HIV care outcomes. Methods A descriptive cross-sectional…

Lineage-Specific Disruption of Hematopoiesis by Oxaliplatin: Mechanisms of Erythropoietin Resistance and Immune Suppression

Feb 2026 DOI 10.14302/issn.2372-6601.jhor-25-5944
Mikhail Y. BerezinCorresponding author

Background Oxaliplatin, a widely used chemotherapeutic agent, is associated with hematologic toxicities such as anemia, leukopenia, and thrombocytopenia. Despite their clinical relevance, the molecular mechanisms underlying lineage-specific bone marrow suppression remain poorly understood. Methods W…

Exploring the Mechanism of Complex Lemon-Angelica Sinensis-Boswellia Essential Oil on Anxiety Disorders with Melasma Through Network Pharmacology and Experimental Validation

Dec 2025
Liping LiuCorresponding author

The incidence rate of melasma is notably high among patients with anxiety disorders. Aromatherapy primarily influences the physiological and psychological states of individuals through the inhalation or application of essential oils, thereby facilitating the treatment or alleviation of various condi…

Detection of carbapenem resistance mechanisms among Avian Pathogenic Escherichia coli (APEC) isolated from broiler chickens

May 2023 DOI 10.14302/issn.2575-1212.jvhc-23-4521
Aya El- shaerCorresponding author

Background The emergence and spread of carbapenem-resistant gram-negative bacteria pose a serious threat to human health. Currently, little is known about the molecular mechanisms underlying carbapenem -resistance and their prevalence among APEC in Egypt. The aim of this study was to detect APEC in…

Two-Phase Lung Damage Mechanisms For COVID-19 Disease, and Driving Force and Selectivity in Leukecyte Recruitment and Migration

Mar 2022 DOI 10.14302/issn.2642-9241.jrd-22-4132
Jianqing WuCorresponding author

To understand lung damages caused by COVID-19, we deduced two phases lung damage mechanisms. After the lungs are infected with COVID-19, the affected lung tissue swells and surface properties of pulmonary capillaries change, both contributing to an increased flow resistance of the capillaries. The i…

Some Regulation Mechanisms of Candidate Genes for Human Cardiovascular Diseases

Mar 2021 DOI 10.14302/issn.2329-9487.jhc-21-3742
Tesfaye SisayCorresponding author

Cardiovascular disease is actually a major cause of mortality, illness and hospitalization worldwide. Several risk factors have been identified that are strongly associated with the development of cardiovascular disease. Public prevention strategies have relied predominately on managing environmenta…

Causes and Self-regulatory Mechanisms of Frustration: A Qualitative Exploration of Rock Climbers

Sep 2020 DOI 10.14302/issn.2644-1101.jhp-20-3524
Yuannan ZhengCorresponding author

In recent years, rock climbing has become increasingly popular around the world. However, due to its challenging and competitive nature, it is common for rock climbers to encounter frustration. It leads to negative emotions, reducing participation, and withdrawal behavior, which requires effective s…

The Mechanism of Decline of Senescent Skeletal Muscle Satellite Cell Self-Renewal and Regenerative Proliferation: The Role of Heparan Sulfate-FGF-2--FGFR1-p38αMAPK Axis, Sprouty1, miR-1, miR-133 and miR-29a

Apr 2020 DOI 10.14302/issn.2832-4048.jsm-20-3211
John PapaconstantinouCorresponding author

Aging mammalian skeletal muscle satellite cells (MuSCs) undergo a decline of stem cell/progenitor cell proliferative and regenerative capacity, and the development of a physiological milieu characteristic of a state of chronic sterile inflammation. p38αMAPK and ERK1/2 are two major signaling pathway…

Cognitive Mechanism of Emotional Validity Influencing Conflict Control

Mar 2019 DOI 10.14302/issn.2574-612X.ijpr-18-2460
Song XueCorresponding author

Conflict control is the ability to choose relevant information and ignore disturbing information in task processing. Previous studies have found that emotions have a certain influence on conflict control, and the research results of positive emotions and negative emotions affect conflict control are…

Action Mechanisms and Therapeutic Targets of Renal Fibrosis

Nov 2018 DOI 10.14302/issn.2574-4488.jna-18-2443
Wei SuCorresponding author

Renal fibrosis was a chronic and progressive process affecting kidneys in chronic kidney disease (CKD), regardless of cause. Although no effective targeted therapy yet existed to retard renal fibrosis, a number of important recent advances have highlighted the cellular and molecular mechanisms under…

Flame Propagation Model and Combustion Phenomena: Observations, Characteristics, Investigations, Technical Indicators, and Mechanisms

Jul 2018 DOI 10.14302/issn.2642-3146.jec-18-2232
Loai AljerfCorresponding author

Critical conditions are usually obtained for ignition in a self-heating solid system consisting of two components generating heat independently, one component being inexhaustible and the other exhaustible by either simple first order or autocatalytic reaction. Ignition depends upon whether the exhau…

Endocrine Disrupting Chemicals: Epigenetic Relevance and Mechanisms

May 2018
Ioannis AlatsathianosCorresponding author

Genetics alone cannot thoroughly expound the environmental impact on the molecular complexity of the endocrine system. Epigenetic-induced alteration in gene expression has emerged as a way in which environmental compounds may exert endocrine effects. The environmental compounds that interfere with n…

Investigations of Molecular Evolutionary Mechanisms in Partially Sequenced Heat Shock Protein70 Homologue-Coding Gene of Olive Leaf Yellowing-Associated Virus Isolates from Tunisia

Feb 2016 DOI 10.14302/issn.2575-7881.jdrr-15-849
Moncef BOULILACorresponding author

Reverse Transcription Polymerase Chain Reaction (RT-PCR) using new designed primers pair for Heat Shock Protein70 homologue (HSP70h) of Olive leaf yellowing-associated virus revealed 667 amplified product of 10 olive accessions collected from various olive-growing regions in Tunisia. Amplicons were…

Mechanisms Associated with Acquisition of Resistance to Butyrate-Induced Apoptosis in Colorectal Cancer Cells Using Gene Expression Analysis

Dec 2014 DOI 10.14302/issn.2326-0793.jpgr-14-598
Kim YC FungCorresponding author

Colorectal cancer is one of the most commonly diagnosed cancers worldwide and its prevalence can be reduced by changes to lifestyle and diet. Fermentation of dietary fibre by the gut microbiota and formation of short chain fatty acids, in particular butyrate, is widely thought to play a role in prev…

Use of Stem Cell Growth and Differentiation Factors (Scdsf) in Central Vertigo

Oct 2026 DOI 10.14302/issn.2379-8572.joa-26-6454
Giorgia GrappeggiaCorresponding author

The clinical use of SCDSF factors in neuro-degenerative pathologies offers a potential therapeutic opportunity. Our observational study aims to evaluate its efficacy in patients affected by Central Vertigo1. A case series divided into two subgroups, all affected by non-migrainous central vertigo, wa…

Obesity and Type 2 Diabetes Impacts on Late Life Bone Fragility, Falls, and Fractures: A Narrative Review and Commentary

Sep 2026 DOI 10.14302/issn.2474-7785.jarh-26-6471
Ray MarksCorresponding author

Sound bone health and the ability to respond effectively to unexpected mobility obstacles that heighten falls risks are crucial for mediating many life affirming activities at all ages, but may be impacted adversely over the course of time by multiple factors, such as excess body weight and its link…

The Advantages of Employing the Immune Response Mediated by Immunoglobulins in Preclinical and Clinical Research: An Essential Review

Sep 2026
Yilkal Tariku BelayCorresponding author

Immunoglobulins, commonly known as antibodies, are glycoprotein molecules present on B lymphocytes and within the bloodstream. They are essential components of the immune response, as they detect the harmful molecules of test compounds and stimulate the immune system to manifest proportional counter…

High-Throughput Complex Disease Modeling for Ethical Drug Discovery: Clinical Relevance of a NAM Platform for Cancer Biomarker Development

May 2026 DOI 10.14302/issn.2572-3030.jcgb-26-6307
Arne-C. FaisstCorresponding author

The development of tumor biomarkers derived from blood, or its components, has become pivotal in advancing early cancer diagnosis. Malignant transformations induce cancer-specific alterations in the transcriptome, proteome, and secretome of tumor cells. Recent studies highlighted similar alterations…

Intravascular Laser Irradiation of Blood (ILIB) on Sleep Quality Improvement: A Randomized Placebo-Controlled Clinical Trial

May 2026 DOI 10.14302/issn.2574-4518.jsdr-25-5773
Lucas Peres de SousaCorresponding author

Introduction Sleep quality is a fundamental determinant of human health and well-being. Modified Intravascular Laser Irradiation of Blood (ILIB), a non-invasive therapeutic modality, has emerged as a potential intervention for sleep-related disturbances. Proposed mechanisms include reduced blood vis…

A New Model of Body Composition: Concept and Design Features of the DBA-Model

Apr 2026 DOI 10.14302/issn.2574-450X.jom-26-6138
Nicolaus DahlmannCorresponding author

Indices, based on data such as height and weight in general and in particularly the body mass index (BMI), are often used to assess overweight. However, there is limited capacity to differentiate the amount of fat mass between individuals. This review refers to an anthropometric model called Dahlman…

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