Search results for “placebo”

About 13 results in articles

Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing articles matching placebo — open any to read the full text, or download the PDF or XML.

Intravascular Laser Irradiation of Blood (ILIB) on Sleep Quality Improvement: A Randomized Placebo-Controlled Clinical Trial

May 2026 DOI 10.14302/issn.2574-4518.jsdr-25-5773
Lucas Peres de SousaCorresponding author

Introduction Sleep quality is a fundamental determinant of human health and well-being. Modified Intravascular Laser Irradiation of Blood (ILIB), a non-invasive therapeutic modality, has emerged as a potential intervention for sleep-related disturbances. Proposed mechanisms include reduced blood vis…

Efficacy and Safety of Pulsed Magnetic Therapy in Sleep related Disorders: A Remote, Randomized, Double-Blind, Placebo-Controlled Trial

Mar 2026 DOI 10.14302/issn.2574-4518.jsdr-26-6010
Peter MarmannCorresponding author

Background/Aim Sleep disturbances are common and are associated with impaired daytime functioning, reduced quality of life, and increased health risks. Non-pharmacological neuromodulatory interventions have gained interest as alternatives to hypnotic medication. Pulsed electromagnetic field (PEMF) t…

A 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating the Efficacy and Safety of DKB-131 in Knee Arthritis

Jun 2024 DOI 10.14302/issn.2379-7835.ijn-24-5117
Do Hoon KimCorresponding author

In this study, the efficacy and safety of DKB-131 (extract of Siraitiagrosvenorii) in adults of both genders presenting mild symptoms of knee arthritis were evaluated in comparison to a placebo. This clinical trial was randomized, double-blind, multicenter, and lasted for 12 weeks. A total of 120 pa…

Evaluation of Acacia- Guar Gum Combination as Delayed Release Coating Former on Solid Placebo Tablets

Feb 2021 DOI 10.14302/issn.2328-0182.japst-21-3700
Suad Y. AlkaribCorresponding author

Objectives The present study addresses evaluation of acacia-guar gum combination as an enteric former for tablet coating aiming to add knowledge on how develop the ability of enteric forming ability of acacia-guar combination. Methods Five formulations of enteric coating solution incorporating guar…

A Triple-Blind, Placebo-Controlled Randomized Trial of the Effect of Bilateral Alternating Somatosensory Stimulation on Reducing Stress-Related Cortisol and Anxiety During and After the Trier Social Stress Test

Jun 2019 DOI 10.14302/issn.2576-6694.jbbs-19-2784
Ernesto Cesar Pinto Leal-JuniorCorresponding author

The aim of this clinical study was to determine the efficacy of bilateral alternating somatosensory stimulation for the management of stress and anxiety during and after the Trier Social Stress Test (TSST), a laboratory procedure for reliably inducing stress in human subjects. For this, a randomized…

Effect of Coenzyme Q 10 Supplementation on Statin-Induced Myalgia, A Randomized Double-Blind, Placebo-Controlled Study

Apr 2016 DOI 10.14302/issn.2474-3585.jpmc-15-704
David RottCorresponding author

Objective: Statins are highly effective medications for reducing low-density lipoprotein cholesterol concentrations and cardiovascular events. Their most common side effects are a variety of myopathic complaints, possibly due to reduced circulating Coenzyme Q10 (CoQ10) levels. We sought to determine…

Etodolac, A Preferential COX-2 Inhibitor, does not Inhibit Platelet Aggregation in a Randomized Placebo-Controlled Trial

Jan 2013 DOI 10.14302/issn.2328-0182.japst-12-99
Wolfgang C KorteCorresponding author

To date, platelet aggregation studies have not been formally evaluated in persons receiving Etodolac, a preferential cyclooxygenase-2 (COX-2) inhibitor. Our purpose was to investigate the influence of Etodolac in therapeutic (analgesic) doses (300 mg every 12h) on platelet aggregation as compared to…

Cross-Reactivity between COX-2 Inhibitors in Patients with Cross-Reactive Hypersensitivity to NSAIDs

Sep 2022 DOI 10.14302/issn.2641-4538.jphi-22-4238
Sevim BavbekCorresponding author

The safety of cyclooxygenase (COX)-2 inhibitors has been tested in patients who had cross-reactive hypersensitivity reactions (HSRs) to nonsteroidal anti-inflammatory drugs (NSAIDs). However, these studies have been mainly done before the current classification of NSAID hypersensitivity and cross-re…

Pilot Study: Impact of a Gluten-Free Diet on Symptoms and Severity of Fibromyalgia

Feb 2020 DOI 10.14302/issn.2379-7835.ijn-20-3201
Ana Carolina Garcia de las Ballonas CampolinaCorresponding author

Fibromyalgia (FM) is a condition of chronic and widespread pain, with several associated symptoms. Previous studies suggested that gluten could influence the severity and frequency of FM symptoms. This work aimed to assess the impact of a gluten-free diet (GFD) in the symptoms and severity of this d…

Ultraviolet B Phototherapy Intervention in Patients with Multiple Sclerosis: A Prospective, Randomized Pilot Trial

Aug 2019 DOI 10.14302/issn.2470-5020.jnrt-19-2797
Catherine A Best-PopescuCorresponding author

Background There is substantial evidence, from well-conducted epidemiological studies, that low vitamin D levels are correlated with increased risk for MS, and multiple case control studies have implicated the involvement of vitamin D deficiency in MS etiology. Narrow-band Ultraviolet B (NB-UVB; 300…

Efficacy of DHA and EPA on Serum Triglyceride Levels of Healthy Participants: Systematic Review

Jan 2019 DOI 10.14302/issn.2379-7835.ijn-18-2469
Yohei KawasakiCorresponding author

Background Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are categorized as omega-3 poly unsaturated fatty acids (PUFAs) that are present in fish oil, etc. DHA and EPA omega-3 PUFAs have a well-established fasting serum triglycerides (TG) lowering effect that may result in normal lipide…

Efficacy and Safety of Lycoprozen®, a Novel Tomato-Based Food Supplement in Patients with Benign Prostatic Hyperplasia

Dec 2018 DOI 10.14302/issn.2379-7835.ijn-18-2491
Stefano IacobelliCorresponding author

Objective: To evaluate the efficacy and safety of a novel tomato-based food supplement on the lower urinary tract symptoms (LUTS) of patients with benign prostatic hyperplasia (BPH). Methods: Twenty patients with BPH were enrolled in this observational study. They were assigned to consume daily a sa…

Rhabdomyolysis in a HIV-infected Patient Following the Addition of Raltegravir, A Case Report with Review of the Literature

Nov 2013 DOI 10.14302/issn.2324-7339.jcrhap-13-304
Alexandria Garavaglia WilsonCorresponding author

Antiretrovirals have traditionally been associated with much toxicity. Newer antiretrovirals are considered much less toxic relative to older antiretrovirals. Upon its FDA-approval in 2009, raltegravir’s adverse drug reaction profile was found to be similar to placebo. However, recently there have b…

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